So, binimetinib is this pill that’s mainly used with another drug called encorafenib to help with melanoma, the kind that has this BRAF V600E/K thing going on. You can get it as these 15 mg tablets with a coating. For grown-ups, they usually say you should take 45 mg of it, twice a day.
It comes in bottles, each with 84 of these tablets. It works by stopping something called the MEK signaling pathway, which is kind of like this superactive thing in melanoma cells that’s part of the MAPK/ERK thing. Binimetinib and stuff like it are meant to keep tumors from growing and spreading when they have this genetic change.
It kind of stops this MEK enzyme from doing its thing, which is like turning on the MAPK pathway. This, in turn, cuts down on stuff like Erk1/2, and that helps slow down the growth of those BRAF-mutant cancer cells.
